Kule minyaka ilishumi idlulileyo, uphando kunye nophuhliso lwamachiza e-ophthalmic luye lwakhokelela kwiindlela ezintsha zokuhambisa, ezifana nokufakelwa kwexesha-ukuhanjiswa kunye ne-mucus-penetrate nanoparticles, enokuphucula ukusebenza kweziyobisi, ukunciphisa imiphumo emibi, kunye nokunciphisa inkxalabo malunga nokuthotyelwa kwesigulane kunye ne-ophthalmic regimens. .amathontsi.iindlela.
Iilensi zoqhagamshelwano zithathwa njengesixhobo esithembisayo, kwaye iilensi ezigqunywe ngamachiza zisaphandwa ngoku losulelo, isifo samehlo esomileyo (DES), iglaucoma, kunye ne-allergies.Nye
Первая контактная линза с лекарственным покрытием, получившая одобрение FDA ранее в этом году (Acuvue Theravision с кетотифеном [Johnson & Johnson Vision]), представляет собой этафилкон А для ежедневного применения, обладающий противовоспалительными свойствами, обычно используемый в глазных каплях от аллергии. I-lens yokuqala yoqhagamshelwano efakwe ngamachiza ukufumana imvume ye-FDA ekuqaleni kwalo nyaka (i-Acuvue Theravision ne-Ketotifen [Johnson & Johnson Vision]), yi-etafilcon yemihla ngemihla ye-anti-inflammatory, esetyenziswa ngokuqhelekileyo kwi-allergy eye drops.ketotifen.
IiLensi zoQhagamshelwano ezininzi ezidumileyo
Iilensi zoqhagamshelwano zisebenza kanye njengamathontsi eliso.2 Ekubeni le ndlela entsha yokufakela, ngexesha lophando lweklinikhi yale lens yoqhagamshelwano, oogxa bam kunye nam siqokelele idatha eyongezelelweyo ukuphelela.
Sihlalutye izilingo zeklinikhi ze-2 kunye ne-multicentre efanayo yoyilo olulawulwa ngokungahleliwe, olubandakanya ngaphezu kwezigulane ze-500.Iziphumo, ezipapashwe kutshanje kwi-Clinical and Experimental Optometry, ipeyinta umfanekiso othembisayo kwizigulane, iingcali, kunye nekamva lobu buchule.3
Ukusetyenziswa kwexesha elide le-eye drops kwaziwa ngokukhokelela kwi-conjunctivitis eyenziwe ngamachiza - ubomvu, ukuvuvukala kunye nokutshiswa kwamehlo emva kokuvezwa ixesha elide kwizithako zamaconsi (ikakhulukazi i-preservatives).ezine
Oku kuphazamiseka akuphazamisi nje kuphela imisebenzi yemihla ngemihla yesigulane kunye nomgangatho wobomi, kodwa kwakhona kuthintela isigulana ukuba siqhubeke sisebenzisa amathontsi eliso kuba isigulane asifuni ukongeza amathontsi angaphezulu kwiliso esele licaphukile.5
Xa isigulane sinale meko, i-corneal staining ihlala ibonisa ukuphazamiseka kwengqibelelo ye-corneal epithelium, ebonisa ukuba unyango kufuneka lulungiswe ukuze luncede iliso liphilise kwaye lithintele umonakalo ongakumbi.
Ukuphepha ukudibana neekhemikhali ezirhabaxa, ezifana namehlo onakaliswe ngumzimba, kubaluleke ngakumbi ekwehliseni i-conjunctivitis eyenziwe ngamachiza.
I-dosing rhoqo isoloko ifunwa ngenxa yokuba amaconsi e-eye ane-bioavailability ephantsi-kuphela i-5-10% yeziyobisi ekhoyo kumphezulu we-eye6-kwaye ihlanjwe ngokukhawuleza ngokuqhwanyaza kunye ne-lacrimation.
Iilensi zoqhagamshelwano ezifakwe ngamayeza zibonelela ngenani leenzuzo ezinokuphelisa ezinye zeengxaki ezinxulumene namathontsi eliso, kubandakanya:
Ichiza longezwa kwi-lens ngexesha lenkqubo yokuvelisa, ekwabandakanya inyathelo le-autoclave sterilization.Ngoko ke, abafuni izilondolozo ezifana ne-BAC, eziqhawula amabhondi phakathi kweeseli ze-corneal epithelial.Ilensi nganye ibonelela ngedosi enyumba yechiza.
Iilensi zoqhagamshelwano ezigqunywe ngamayeza zihambisa iyeza kwiiyure nje ezimbalwa, ngoko zihlala phezu kweliso ixesha elide kunamathontsi eliso ahlamba ngokukhawuleza.Iprofayili yokukhutshwa esekwe kwi-diffusion yeelensi zoqhagamshelwano ibavumela ukuba banikeze iidosi ezingaguquguqukiyo kunedosi eqhelekileyo efunekayo kwamanye amathontsi eliso.
Ngokudibanisa unyango lwezonyango kunye nokulungiswa kombono kwi-etafilcon ekhululekile I-lens yokudibanisa elahlayo, izigulane azidingi ukucinga ngeshedyuli yamayeza.Le yinzuzo ethembisayo ngokukodwa kwizigulane ezifumana kunzima ukuhlala kwishedyuli.
Iilensi zoqhagamshelwano ezifakwe ngamayeza zinokucombulula ezinye zeengxaki ezinxulumene nokuthotywa kwamehlo, kodwa umbuzo olandelayo onengqiqo wabasebenzi bokhathalelo lwamehlo ngulo, “Ziyintoni iziphumo zokunxiba iilensi zamayeza mihla le kumphezulu weliso?”
IiLensi zoQhagamshelwano ezininzi ezidumileyo
Oogxa bam kunye nam sahlalutya idatha evela kwiimvavanyo zokhuseleko lweklinikhi ezifanayo eziye zathatha iiveki ze-12 kwaye zibandakanya inani elipheleleyo lama-560 abanxibe iilensi zoqhagamshelwano.Izigulana ezingama-374 zazinxibe iilensi zovavanyo kwaye izigulane ezingama-186 zazinxibe iilensi ze-placebo.
I-Cornea staining nge-fluorescein yenziwa ekuqaleni kwaye emva kwe-1, 4, 8, kunye ne-12 yeeveki zokunxiba iilensi.Kwakungekho mahluko ubalulekileyo ngokweenkcukacha-manani ekungcoleni phakathi kweqela le-lens eligqunywe ngamachiza kunye neqela le-placebo kulo lonke utyelelo (95.86% kunye ne-95.88% yebakala 0, ngokulandelelanayo, kwiiveki ezili-12).Onke amabala ayekhaphukhaphu okanye umkhondo.
Emva kweeveki ezi-4 zokunxiba, omabini amaqela afumana ukuncitshiswa kwe-corneal staining ukusuka kwisiseko.Olu tshintsho olubonakalayo lunokuba ngenxa yezigulane ezitshintshela kwiilensi zazo eziqhelekileyo ukuya kwizinto ezintsha (etafilcon A, enomxholo ophezulu wamanzi7) kunye / okanye irejimeni yokugqoka (kanye ngosuku, ethatha i-equation ngaphandle kwe-equation) ukucoca. iilensi zesisombululo).Ukubambelela kwiilensi zophononongo kwakufana kumaqela omabini (malunga nama-92%).
Ukuqukumbela, kwisifundo esikhulu, esilawulwa kakuhle, esisiyimfama esiphindwe kabini, sinokugqiba ngokuzithemba ukuba le lens yokudibanisa i-antihistamine ayichaphazeli kakhulu ingqibelelo ye-corneal epithelium.
Amehlo anxibe ezi lens zoqhagamshelwano ezigqunywe ngamachiza akufuneki ajongeke ngokwahlukileyo kunamehlo anxibe iilensi zoqhagamshelwano ezingasebenzisi mayeza, nto leyo ebaluleke kakhulu ekudityanisweni okungenamthungo kwindlela yokwenza le modyuli.
Akukho mahluko kwinkqubo yokufaka iilensi okanye ukuvavanya umbono.Izigulana zifuna nje ukwazi ngakumbi malunga neelensi ukuze zifumane umbono eziwufunayo kwaye zifumane uncedo olongezelelekileyo ngokwaliwa kwamehlo.
Ubungqina bokuba ukongezwa kwe-antihistamines akunyusi umonakalo we-corneal epithelial xa kuthelekiswa ne-standard contact lens buyakhuthaza njengoko sijonge phambili kwisicelo esingakumbi seendlela ezifakwe ngamachiza.
Ixesha lokuposa: Aug-18-2022
